Autor: |
Jean-Alain Fehrentz, Jean Martinez, Annie Heitz, Vincent Guerlavais, Michèle Cristau, Marielle Paris |
Rok vydání: |
1998 |
Předmět: |
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Zdroj: |
Tetrahedron Letters. 39:7287-7290 |
ISSN: |
0040-4039 |
Popis: |
A new strategy for the synthesis of peptide aldehydes on solid support is presented. Reaction of a N-protected α-amino aldehyde with MBHA-supported Wittig ou Wittig-Horner reagent yielded resin-linked α-β-unsaturated δ-amino derivative. After elongation of the peptide chain, ozonolysis produced fairly pure C-terminal peptide aldehydes in good yield. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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