Synthesis of peptide aldehydes on solid support using ozonolysis

Autor:	Jean-Alain Fehrentz, Jean Martinez, Annie Heitz, Vincent Guerlavais, Michèle Cristau, Marielle Paris
Rok vydání:	1998
Předmět:	chemistry.chemical_classification Ozonolysis Organic Chemistry Peptide Biochemistry Aldehyde chemistry.chemical_compound chemistry Yield (chemistry) Reagent Drug Discovery Wittig reaction Organic chemistry Derivative (chemistry)
Zdroj:	Tetrahedron Letters. 39:7287-7290
ISSN:	0040-4039
Popis:	A new strategy for the synthesis of peptide aldehydes on solid support is presented. Reaction of a N-protected α-amino aldehyde with MBHA-supported Wittig ou Wittig-Horner reagent yielded resin-linked α-β-unsaturated δ-amino derivative. After elongation of the peptide chain, ozonolysis produced fairly pure C-terminal peptide aldehydes in good yield.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::856bdaab2dca1f8b3101db37a66a5763 https://doi.org/10.1016/s0040-4039(98)01559-7 Zobrazit plný text záznamu Full Text from ScienceDirect