| Autor: |
Agostina Palmigiano, Francesco Fumarola, Daniel P. Mossing, Nataliya Kraynyukova, Kenneth D. Miller, Hillel Adesnik |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.1101/2020.11.11.378729 |
| Popis: |
Predicting the response of the cortical microcircuit to perturbations is a prerequisite to determine the mechanisms that mediate its response to stimulus; yet, an encompassing perspective that describes the full ensemble of the network’s response in models that accurately recapitulate recorded data is still lacking. Here we develop a class of mathematically tractable models that exactly describe the modulation of the distribution of cell-type-specific calcium-imaging activity with the contrast of a visual stimulus. The inferred parameters recover signatures of the connectivity structure found in mouse visual cortex. Analysis of this structure subsequently reveals parameter-independent relations between the responses of different cell types to perturbations and each interneuron’s role in circuit-stabilization. Leveraging recent theoretical approaches, we derive explicit expressions for the distribution of responses to partial perturbations which reveal a novel, counter intuitive effect in the sign of response functions. Finally applying the theory to inferring feedback to V1 during locomotion, we find that it is predominantly mediated by both SOM and VIP modulation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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