Tricyclic cephems as inhibitors of human leukocyte elastase. Furo[3,4-c]cepham sulfones

Autor:	Ettore Perrone, Pierluigi Bissolino, Riccardo Corigli, Vincenzo Rizzo, Marco Alpegiani
Rok vydání:	1995
Předmět:	chemistry.chemical_classification Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Cleavage (embryo) Biochemistry Human Leukocyte Elastase Hydrolysis Reaction rate constant chemistry Drug Discovery Molecular Medicine Molecular Biology Tricyclic
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 5:687-690
ISSN:	0960-894X
Popis:	Furo[3,4-c]cepham sulfones were efficiently obtained from 1,1-dioxo-3-methylcephem-4-ketones. Cyclization improved at one time stability of the β-lactam towards hydrolytic cleavage (pH 7.4) and reactivity (second-order inhibition rate constant kon) towards human leukocyte elastase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::854f58bb244a39858568a13864231da1 https://doi.org/10.1016/0960-894x(95)00094-a Zobrazit plný text záznamu Full Text from ScienceDirect