Conditional knockout of TOG results in CNS hypomyelination
| Autor: | Miki Furusho, Joshay Ford, Jessica W. Tutolo, Kristine H. Le, Rashmi Bansal, Michael J. Maggipinto, Elisa Barbarese, John W Wizeman |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
CNS hypomyelination Regulation of gene expression Cerebellum biology Molecular biology Oligodendrocyte Myelin basic protein 03 medical and health sciences Cellular and Molecular Neuroscience Myelin 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure nervous system Neurology Conditional gene knockout Gene expression medicine biology.protein 030217 neurology & neurosurgery |
| Zdroj: | Glia. 65:489-501 |
| ISSN: | 0894-1491 |
| DOI: | 10.1002/glia.23106 |
| Popis: | The tumor overexpressed gene (TOG) protein is present in RNA granules that transport myelin basic protein (MBP) mRNA in oligodendrocyte processes to the myelin compartment. Its role was investigated by conditionally knocking it out (KO) in myelinating glia in vivo. TOG KO mice have severe motor deficits that are already apparent at the time of weaning. This phenotype correlates with a paucity of myelin in several CNS regions, the most severe being in the spinal cord. In the TOG KO optic nerve |
| Databáze: | OpenAIRE |
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