Occult hemorrhage in children with severe ITP
| Autor: | George R. Buchanan, Adolfo Flores |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Urinalysis medicine.diagnostic_test business.industry Urinary system Fecal occult blood Physical examination Hematology 030204 cardiovascular system & hematology Gastroenterology Surgery 03 medical and health sciences Purpura 0302 clinical medicine Hemosiderin Internal medicine Medicine medicine.symptom Microscopic hematuria business Prospective cohort study 030217 neurology & neurosurgery |
| Zdroj: | American Journal of Hematology. 91:287-290 |
| ISSN: | 0361-8609 |
| DOI: | 10.1002/ajh.24264 |
| Popis: | Little is known about the frequency and significance of clinically unapparent or occult hemorrhage in ITP. Therefore, we prospectively explored the sites and frequency of occult bleeding in children with severe ITP at diagnosis or upon symptomatic relapse in a prospective, single-institution cohort study of patients ≤ 18 years of age and a platelet count ≤ 10,000/mm(3) . Data collected included bleeding severity assessment, urinalysis, fecal occult blood testing, and non-contrast brain MRI. Stool and urine samples were tested within 7 days of diagnosis or symptomatic relapse. Three months after diagnosis or relapse a noncontrast brain MRI evaluated hemosiderin deposits resulting from prior localized hemorrhage. Fifty-two ITP patients were enrolled with a mean platelet count of 4,000/mm(3) . A significant occurrence of occult hemorrhage was identified in the urine (27%) compared with clinically overt hematuria (0.91%, P |
| Databáze: | OpenAIRE |
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