One-Step Synthesis of C2v-Symmetric Resorcin[4]arene Tetraethers
Autor: | Nigel T. Lucas, Simon B Petrie, Thomasin K Brind, Jordan N. Smith, Mikaela S Grant |
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Rok vydání: | 2020 |
Předmět: | |
Zdroj: | The Journal of Organic Chemistry. 85:4574-4580 |
ISSN: | 1520-6904 0022-3263 |
Popis: | The three-component reaction between a resorcinol, 1,3-dimethoxybenzene, and an alkyl aldehyde (R = C1-C11) along with BF3·OEt2 affords a C2v-symmetric resorcin[4]arene tetraether in one step; in most cases, the single isomer can be precipitated from the reaction mixture in moderate to excellent yields (up to 89%). The reaction is tolerant of 2-substituted resorcinols (R' = OH, Cl, Br, Me), allowing a third type of functionality to be regioselectively incorporated during the macrocyclization. |
Databáze: | OpenAIRE |
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