Four New Compounds Isolated from the Aerial Part of Belamcanda chinensis (L.) and Their Effect on Vascular Smooth Muscle Cell (VSMC) Proliferation
| Autor: | Nguyen Thi Thu, Do Thi Ha, Won Keun Oh, Nguyen Thi Bich Thu, Pham Ha Thanh Tung, Bui Thi Binh |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Ethanol
Vascular smooth muscle 010405 organic chemistry Cell Irigenin General Chemistry General Medicine Fractionation 010402 general chemistry 01 natural sciences 0104 chemical sciences VSMC proliferation Iridaceae chemistry.chemical_compound medicine.anatomical_structure Biochemistry chemistry Drug Discovery Belamcanda chinensis medicine |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 67:41-46 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | Bio-guided fractionation of the 70% ethanol extract of Belamcanda chinensis (L.) DC. revealed four new compounds, including 6″-O-acetylembinin (5), 3″-O-acetylembinin (6), irigenin 3'-O-β-glucopyranoside (8), and 2'-acetyl-1,3-O-diferuloylsucrose (9), along with five known compounds (1-4, 7). Their chemical structures were determined using extensive NMR data, mass spectroscopy, and comparison with published literature. Among the isolates, compounds 1 and 4-7 achieved good regulation of the growth and proliferation of vascular smooth muscle cells. |
| Databáze: | OpenAIRE |
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