485Prospective associations between sex hormone-binding globulin and risk of type 2 diabetes

Autor:	Min-Ho Shin, Bo Youl Choi, Hye Won Woo, Mi Kyung Kim
Rok vydání:	2021
Předmět:	medicine.medical_specialty biology Epidemiology business.industry General Medicine Type 2 diabetes medicine.disease Menopause Sex hormone-binding globulin Endocrinology Insulin resistance Internal medicine medicine biology.protein Fasting blood glucose measurement business
Zdroj:	International Journal of Epidemiology. 50
ISSN:	1464-3685 0300-5771
DOI:	10.1093/ije/dyab168.718
Popis:	Background Circulating sex hormone–binding globulin levels are inversely associated with insulin resistance. However, epidemiologic evidence on the association of sex hormone-binding globulin (SHBG) and the risk of developing diabetes is limited. This study aimed to evaluate the prospective associations between serum SHBG level and risk of type 2 diabetes (T2D) among adults ≥ 40 years old in the Yangpyeong and Namwon cohort. Methods A total of 4,383 (1,651 men and 2,732 women) participants who did not have T2D were enrolled. The incidence rate ratio (IRR) was estimated using a modified Poisson regression model with a robust error estimator. During follow-up (27,146 person-years), 284 T2D cases were newly diagnosed. Results Significant dose-response inverse associations were observed between serum SHBG (tertiles) and T2D in women, even after controlling for baseline fasting glucose (incidence rate ratio, IRR=0.42, 95% CI = 0.26–0.68, P for trend = Conclusions Serum SHBG may be inversely associated with T2D in women, but not in men. Key messages Circulating SHBG may play different roles in the development of T2D in men and women.
Databáze:	OpenAIRE
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