Risk factors of disease activity in patients with Behçet’s syndrome

Autor: Cheng-Cheng Hou, Jian-Long Guan
Rok vydání: 2020
Předmět:
Zdroj: Clinical Rheumatology. 40:1465-1471
ISSN: 1434-9949
0770-3198
DOI: 10.1007/s10067-020-05386-9
Popis: To investigate the clinical characteristics and laboratory data in Behcet’s syndrome (BS) patients in China and analyze the risk factors of disease activity. A retrospective analysis method was used and the demographic data and laboratory results were collected from 174 BS patients. Univariate and multivariate logistic regression analyses were used to analyze the demographic data and laboratory indexes whether that are risk factors or not of disease activity. The most common clinical manifestations of BS patients enrolled were mouth ulceration (48.85%), followed by erythema nodosum (20.69%), and eye involvement (13.75%), while the least common was headache (0%). Most active BS patients (96.55%) used 2 or ≥ 3 immunosuppressants to control disease, while most inactive patients (75%) used 0 or 1 immunosuppressant. The associated risk factors of disease activity consisted of disease duration, neutrophil-to-lymphocyte ratio (NLR), white blood cells, red blood cells, hemoglobin, platelets, fibrin degradation products, IgG, IgM, complement 3, complement 4, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), albumin, albumin-to-globulin ratio (AGR), and high-density lipoprotein (HDL) (P < 0.05 or P = 0.00). Disease duration (≤ 60 months) (OR 8.49, 95% CI 2.09–34.49, P = 0.003), NLR (≥ 2) (OR 8.68, 95% CI 2.12–35.49, P = 0.003), CRP (≥ 10 mg/L) (OR 41.12, 95% CI 8.43–200.70, P = 0.000), ESR (≥ 20 mm/H) (OR 9.60, 95% CI 2.41–38.18, P = 0.001), and AGR (< 1.5) (OR 12.42, 95% CI 2.92–52.80, P = 0.001) were the independent risk factors of disease activity in BS patients. Attention should be paid to the risk factors of disease activity and the medicine should be adjusted correspondingly.
Databáze: OpenAIRE
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