Targeted Therapy in Pediatric AML: An Evolving Landscape
| Autor: | Katherine Tarlock, Todd Cooper, LaQuita M Jones |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Chemotherapy business.industry medicine.medical_treatment MEDLINE Hematopoietic stem cell Diagnostic tools Pediatric AML Targeted therapy Pharmacotherapy medicine.anatomical_structure hemic and lymphatic diseases Pediatrics Perinatology and Child Health medicine Pharmacology (medical) Intensive care medicine Adverse effect business |
| Zdroj: | Pediatric Drugs. 23:485-497 |
| ISSN: | 1179-2019 1174-5878 |
| DOI: | 10.1007/s40272-021-00467-x |
| Popis: | The outcomes associated with pediatric acute myeloid leukemia (AML) have improved over the last few decades, with the implementation of intensive chemotherapy, hematopoietic stem cell transplant, and improved supportive care. However, even with intensive therapy and the use of HSCT, both of which carry significant risks of short- and long-term side effects, approximately 30% of children are not able to be cured. The characterization of AML in pediatrics has evolved over time and it currently involves use of a variety of diagnostic tools, including flow cytometry and comprehensive genomic sequencing. Given the adverse effects of chemotherapy and the need for additional therapeutic options to improve outcomes in these patients, the genomic and molecular architecture is being utilized to inform selection of targeted therapies in pediatric AML. This review provides a summary of current, targeted therapy options in pediatric AML. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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