Treatment of High-Risk Neuroblastoma with Intensive Chemotherapy, Radiotherapy, Autologous Bone Marrow Transplantation, and 13-cis-Retinoic Acid
| Autor: | Richard E. Harris, Garrett M. Brodeur, Patrick S. Swift, Seeger Rc, Daniel O. Stram, Katherine K. Matthay, C. P. Reynolds, Judith G. Villablanca, H. Shimada, Robert B. Gerbing, C T Black, Norma K.C. Ramsay |
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| Rok vydání: | 1999 |
| Předmět: | |
| Zdroj: | New England Journal of Medicine. 341:1165-1173 |
| ISSN: | 1533-4406 0028-4793 |
| Popis: | Background Children with high-risk neuroblastoma have a poor outcome. In this study, we assessed whether myeloablative therapy in conjunction with transplantation of autologous bone marrow improved event-free survival as compared with chemotherapy alone, and whether subsequent treatment with 13-cis-retinoic acid (isotretinoin) further improves event-free survival. Methods All patients were treated with the same initial regimen of chemotherapy, and those without disease progression were then randomly assigned to receive continued treatment with myeloablative chemotherapy, total-body irradiation, and transplantation of autologous bone marrow purged of neuroblastoma cells or to receive three cycles of intensive chemotherapy alone. All patients who completed cytotoxic therapy without disease progression were then randomly assigned to receive no further therapy or treatment with 13-cis-retinoic acid for six months. Results The mean (±SE) event-free survival rate three years after the first randomization was si... |
| Databáze: | OpenAIRE |
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