| Autor: |
Sara Croca, C Pericleous, Filipa Farinha, Maura Griffin, Anisur Rahman, Thomas McDonnell, Andrew Nicholaides, Ian Giles |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Poster presentations. |
| DOI: |
10.1136/lupus-2020-eurolupus.79 |
| Popis: |
Background Cardiovascular disease is a significant burden on SLE patients and no satisfactory markers exist to predict atherosclerotic development in patients. This study utilised an orthogonal approach to develop a marker of cardiovascular progression with predictive value in SLE patients. Methods The earliest available sample from a cohort of 92 SLE patients was tested for anti-Domain I (aDI), anti Beta-2-Glycoprotein-I, and anti-Cardiolipin antibodies. Persistent positivity was not assessed. These patients then had vascular ultrasound scans (carotid and femoral arteries) (mean 10 years later) to assess subclinical atherosclerotic plaque. A range of demographic, clinical and serological markers were recorded at the time of the scan. Predictors of plaque presence were investigated using binary logistic regression. Results A total of 34 patients from the cohort of 92 had atherosclerotic plaque (37%). A total of 32 patients had aDI positivity, of which 20 (62.5%) also had Plaque, this is reflected by the significantly higher levels of aDI antibodies seen in Plaque patients (p Conclusions Early aDI positivity may be a good marker of atherogenesis in SLE patients in the long term. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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