Microwave enhancement of arylation of activated olefins with 4-bromoacetophenone

Autor:	V. V. Zorin, A. U. Ishbaeva, A. R. Chanysheva, S. S. Vershinin, R. N. Shakhmaev
Rok vydání:	2010
Předmět:	Solvent chemistry.chemical_compound chemistry Heck reaction Organic Chemistry Microwave irradiation Substrate (chemistry) Organic synthesis Combinatorial chemistry Decomposition Microwave Catalysis
Zdroj:	Russian Journal of Organic Chemistry. 46:455-456
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428010030280
Popis:	Palladium-catalyzed arylation and vinylation of olefins (Heck reaction) are important reactions in organic synthesis [1, 2]. In most cases, under classical conditions (closed system, no solvent, temperature 100–120°C) complete substrate conversion is attained in several hours to several days [3]. Attempts to carry out the reaction at a higher temperature resulted in decomposition of the catalytic system and formation of by-products. In the recent time, examples of successful application of microwave irradiation to accelerate Heck reactions in polar solvents have been reported [4–8].
Databáze:	OpenAIRE
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