Antioxidant and enzyme inhibitory activities of disodium rabdosiin isolated from Alkanna sfikasiana Tan, Vold and Strid
| Autor: | T. Tufa, Ioanna Chinou, H Damianakos, Gokhan Zengin, Konstantia Graikou |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Antioxidant ABTS Traditional medicine biology Chemistry DPPH Linoleic acid Rosmarinic acid medicine.medical_treatment Plant Science Boraginaceae biology.organism_classification 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Alkanna medicine Quercetin 010606 plant biology & botany |
| Zdroj: | South African Journal of Botany. 120:157-162 |
| ISSN: | 0254-6299 |
| DOI: | 10.1016/j.sajb.2018.04.005 |
| Popis: | Alkanna sfikasiana Tan, Vold and Strid is an endemic Greek species of Boraginaceae family. From the roots, the new natural product disodium rabdosiin (1) along with rosmarinic acid (2) were isolated from the methanolic extract and lanosta-7,24-dien-3β-ol (3) and linoleic acid (4) from the cyclohexane extract. From the methanolic extract of the aerial parts two flavonoids quercetin 3-Ο-β-D-glucoside (5) and quercetin 3-Ο-β-D-rutinoside (6) were isolated. The antioxidant properties exhibited good radical scavenging activity (96.00 mgTE/g for DPPH; 441.97 mgTE/g for ABTS) and reducing power ability (720.81 mgTE/g for CUPRAC and 413.94 mgTE/g for FRAP) for the new compound 1. Enzyme inhibitory activity has been also evaluated, showing inhibitory effects on AChE (4.32 mgGALAE/g), BChE (3.63 mgGALAE/g) and α-amylase (3.83 mmolACAE/g). Consequently, our study could provide a potential candidate for developing novel phyto-pharmaceutics and it could be considered a new starting point on the studied species. |
| Databáze: | OpenAIRE |
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