| Popis: |
Twenty severe pulmonary emboli (8 of which occured within S days of an operation) were treated by the injection, in a few minutes, of 10,000 to 15,000 CTA units/kg of Urokinase by peripheral (6 cases) or central (14 cases) IV route in conjunction with immediate effective heparinization, These severe pulmonary emboli were characterized mainly by a state of shock reversible a few hours after the administration of Urokinase ; 50% devascularization shown by diagnostic angiography, improved by an average of 41% in angiography 5 days after administration of Urokinase; hypoxemia in unaided breathing (average PaO2 : 40 Torr). Three deaths occurred 7, 31 and 40 days after Urokinase. In comparison with classic methods of treatment with Urokinase (UKII 85% - UKI 15%), this procedure is well tolerated, less dangerous (in terms of the bleeding factor), less costly and simpler ; but its efficacy, while evident, should be determined with accuracy. |
