Effect of Synthetic TRF on Prolactin Release in the Sheep1

Autor:	L.R. Fell, Jock K. Findlay, I. A. Cumming, J. R. Goding
Rok vydání:	1973
Předmět:	Diminution medicine.medical_specialty business.industry Radioimmunoassay Plasma prolactin Prolactin Arterial cannulation Arterial catheterization Dose–response relationship Endocrinology Internal medicine medicine Intracarotid Infusion business
Zdroj:	Endocrinology. 93:487-491
ISSN:	1945-7170 0013-7227
DOI:	10.1210/endo-93-2-487
Popis:	Administration of synthetic TRF, either by intravenous injection or intracarotid infusion to anestrous ewes, caused an immediate and substantial pituitary release of prolactin as indicated by plasma prolactin radioimmunoassay. There was evidence of a dose response relationship between the quantity of prolactin secreted and TRF at levels of 0.2-10 μg/hr by intracarotid infusion or 5-20 μg by intravenous injection. Repeated injections of 20 μg TRF resulted in diminution of the response. The non-specific stimulus of arterial cannulation was also shown to elicit the release of prolactin. Synthetic TRF or arterial cannulation had no effect on plasma LH concentration. (Endocrinology 93: 487, 1973)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::84defba8c0bee6311ed07b9b8055a007 https://doi.org/10.1210/endo-93-2-487 Zobrazit plný text záznamu