Determination of Relative Rate Constants for Reactions of 2,2’-Azobis-(2-Amidinopropane) Dihydrochloride Peroxyl Radicals with Dihydroxybenzenes and Their Derivatives
| Autor: | A. V. Belyi, N. I. Belaya, K. V. Glushenko |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pharmacology
010304 chemical physics Hydroquinone 010401 analytical chemistry Kinetics Resorcinol Orcinol 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Reaction rate constant chemistry Computational chemistry 0103 physical sciences Drug Discovery Phenol Phenols 2 2'-Azobis(2-amidinopropane) dihydrochloride |
| Zdroj: | Pharmaceutical Chemistry Journal. 51:230-234 |
| ISSN: | 1573-9031 0091-150X |
| Popis: | An iodometric method for determining the antiradical activity (ARA) of dihydroxybenzenes in the reaction with 2,2′-azobis-(2-amidinopropane) (AAP) peroxyl radicals (rOO• ) in conditions close to those obtaining in biological systems was developed. A means of calculating relative rate constants of reactions of phenols with rOO• from the kinetics of consumption of an inhibitor added at low concentration was proposed. The greatest levels of ARA were seen with resorcinol, orcinol, and hydroquinone, which are able to dissociate to form highly reactive mono-and bianionic forms of phenolate ions. A method of calculating relative rate constants of these reactions was proposed, based on the AAP - AAP peroxyl radical - phenol kinetic model. |
| Databáze: | OpenAIRE |
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