Atypical Gαi Signal Transduction
| Autor: | Peter Zahradka, Raissa Perrault |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pharmacology
biology business.industry G protein GTP-Binding Protein alpha Subunits Receptor tyrosine kinase Cell biology Adenylyl cyclase chemistry.chemical_compound chemistry Cell surface receptor Second messenger system biology.protein Medicine Signal transduction Cardiology and Cardiovascular Medicine business Receptor |
| Zdroj: | Current Vascular Pharmacology. 12:258-270 |
| ISSN: | 1570-1611 |
| Popis: | G protein signaling is an extremely complex event that is involved in almost every cellular process. As such, G protein-coupled receptors are the most commonly found type of transmembrane receptors used by cells to initiate intracellular signaling events. However, the widely accepted model of cyclical GDP-GTP exchange in response to ligand binding to 7TMRs, followed by dissociation of the G protein subunits and activation of intracellular signaling cascades, has repeatedly been challenged in recent years. Some of the exceptions that have been brought forth include signaling by a non-dissociated, rearranged heterotrimer and the existence of "reverse-mode", active G proteins that interact with active receptors. Here, we focus on G(αi/o), one of the common G(α) classes, and outline a major exception to the classical model, that of G protein coupling to RTKs. We then describe a novel concept in G(αi/o) signaling, namely that the pathways induced by agonist binding circumvent the typical signaling pathways responsive to decreases in the second messenger cAMP, via adenylyl cyclase inhibition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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