DNA damage signalling and NF-κB: implications for survival and death in mammalian cells

Autor:	M. P. Boland
Rok vydání:	2001
Předmět:	chemistry.chemical_compound chemistry Apoptosis DNA damage STAT protein NF-κB Protein inhibitor of activated STAT Biology Cell fate determination Biochemistry Transcription factor stat Cell biology
Zdroj:	Biochemical Society Transactions. 29:674-678
ISSN:	1470-8752 0300-5127
DOI:	10.1042/bst0290674
Popis:	Nuclear factor κB (NF-κB), p53 and signal transducer and activator of transcription (STAT) proteins are transcription factors that are known to regulate cell fate in response to apoptotic stimuli. They may, therefore, represent components of drug responses that determine drug efficacy. This review will describe data illustrating some recent progress in our understanding of the mechanism of NF-κB activation after treatment of cells with DNA-damaging anti-cancer drugs. Furthermore, it will discuss how this and other transcriptional events, including STAT transcription factor activation, may effect the promotion or attenuation of apoptosis in target cells. In this regard, certain STAT family members may lie downstream of signalling pathways that are activated after DNA damage. Finally, it will be discussed how proteins normally linked with DNA damage signalling such as p53 may be regulated in response to physiological signals, revealing their role in developmental checkpoints such as differentiation commitment.
Databáze:	OpenAIRE
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