Rearrangement ofN-Allyl-α,α-dichloroamides, β- or γ- Functionalized, to Substituted Analogues of the γ-Aminobutyric Acid (GABA)
| Autor: | Adriano Pinetti, Luca Forti, Franco Ghelfi, Ugo Maria Pagnoni, Emanuela Libertini, Gianluca Ghirardini, Franco Bellesia, Nicola Prochilo |
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| Rok vydání: | 1999 |
| Předmět: | |
| Zdroj: | Synthetic Communications. 29:3739-3748 |
| ISSN: | 1532-2432 0039-7911 |
| Popis: | The rearrangement of γ-chlm, β-hydroxy or β-vmyl N-allyl-N-benzyl-α,α-dichlorocarboxyamides to γ-aminobutynic acid analogues is efficiently promoted by CuCI\N,N,N′,N′-tetramethylethylendiamine. With the β-vinyl functionalization a tandem radical-radical reaction, yieldmg 3-aza-2-oxo-bicyclo[3,3,0]actatre adducts, is also observed. |
| Databáze: | OpenAIRE |
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