Metal Chelates of Tridentate (NNO) 1,2,4-Triazine Schiff Base: Synthesis, Physico-chemical Investigation and Pharmacological Screening
| Autor: | G. R. Priya Dharsini, Clarina Thanaraj, Rama Velladurai |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Schiff base
Polymers and Plastics Chemistry Ligand 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Metal chemistry.chemical_compound Transition metal visual_art Polymer chemistry Octahedral molecular geometry Materials Chemistry visual_art.visual_art_medium Molecule Chelation 0210 nano-technology Triazine |
| Zdroj: | Journal of Inorganic and Organometallic Polymers and Materials. 30:2315-2322 |
| ISSN: | 1574-1451 1574-1443 |
| DOI: | 10.1007/s10904-019-01413-8 |
| Popis: | Present work portray the synthesis of four new tridentate Schiff base ligand transition metal chelates having 1,2,4-triazine and 1,4-Naphthoquinone as a potential drug candidate, with composition ML2, where M=Co(II), Ni(II), Cu(II) and Zn(II); L = 4-(2-(5,6-diphenyl-1,2,4-triazin-3-yl)hydrazono)-3-hydroxynaphthalene-1(4H)-one (DTN). Credible structure of the synthesized compounds was investigated using different techniques like elemental analysis, molar conductance, mass spectra, magnetic susceptibility, UV–Visible, IR, NMR and TGA. The results were unfailing with tridentate nature of the ligand and octahedral geometry of metal chelates. Thermal scrutiny of the synthesized complexes exemplified absence of coordinated water molecules, decomposition patterns of the complexes and their stabilities. Furthermore, redox behaviour of the synthesized compounds was examined by cyclic voltammetry in DMSO solution. Antimicrobial screening tests played a pivotal role in displaying the presence of metal ion in the ligand system. Chemical nuclease activity was investigated to study the DNA cleavage activities of the synthesized compounds and effectual cleavage was revealed by Co(II) and Cu(II) metal chelates of DTN. |
| Databáze: | OpenAIRE |
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