Abstract TP213: Aging Promotes The Rupture Of Intracranial Aneurysm In Mice
| Autor: | Hiroki Uchikawa, Hiroki Sato, Jinglu Ai, Michael Lawton, Satoru Eguchi, Tomoki Hashimoto |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Stroke. 54 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/str.54.suppl_1.tp213 |
| Popis: | Introduction: Aging is a known risk factor for intracranial aneurysm rupture in human clinical studies. However, clinical studies only showed the association, but not the causality of aging and aneurysm rupture. Using our well-established mouse model, we directly tested the hypothesis that aging increases the rupture rate of aneurysms. Methods: We used both male and female C57BL/6J mice at 10 weeks and 18 months of age. We induced intracranial aneurysms by a combination of elastase injection and DOCA-salt hypertension. We compared the formation and rupture rates of intracranial aneurysms and the survival curve between young mice and aged mice of each sex. Results: Aged female mice had a higher rupture rate (86.7% vs 38.9%; P Conclusions: Aging promotes both the formation and rupture of intracranial aneurysms in both male and female mice. These data agree with clinical observations and will serve as a basis for further investigation of the roles of the aging-related biological changes in the development of aneurysm rupture. |
| Databáze: | OpenAIRE |
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