Einpluss von lindau und lindanmetaboliten auf mikro‐somale und mitochondriale ATPasen in vitro

Autor:	Rainer Macholz, Heinevetter D, Roland Plass, Hans-Jochen Lewerenz
Rok vydání:	1985
Předmět:	chemistry.chemical_classification Kidney biology Metabolite ATPase General Medicine Mitochondrion biology.organism_classification Pollution chemistry.chemical_compound Enzyme medicine.anatomical_structure chemistry Microsoma Biochemistry Toxicity biology.protein medicine Microsome Food Science
Zdroj:	Journal of Environmental Science and Health, Part B. 20:539-558
ISSN:	1532-4109 0360-1234
DOI:	10.1080/03601238509372494
Popis:	In vitro investigations of the influence of lindane and its metabolites were performed on microsomal and mitochondrial ATPases from liver, kidney and brain of rat and mouse. The microsomal Na+‐K+‐ATPases in rat liver were inhibited by the tested substances. An increase of activity was observed only with 2,5 × 10 M‐5 gamma‐HCH. Effects on the microsomal Na+‐K+‐ATPase from kidney and brain of rat were also indicated. The mitochondrial enzym in rat liver was stimulated by all the compounds tested at concentrations of 10‐4 M – 10‐2 M. The effects on raitochondrial enzymes from kidney and brain varied in dependence on the tested substances. In the microsomes and mitochondria of mouse an influence on the Na+‐K+‐ATPases similar to the effects on the preparations from organs of rat was evident.
Databáze:	OpenAIRE
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