Significance of Expression of IMP3, PPARG & PD-L1 in Urothelial Carcinoma (Immunohistochemical Study)
| Autor: | Nehal Saad Zafer, Rasha El Sawi, Amr El-Sebaaie, Ebtehal Abdel Aal, Hala A. Agina |
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| Rok vydání: | 2020 |
| Předmět: |
Peroxisome proliferator-activated receptor gamma
biology Lymphovascular invasion business.industry medicine.medical_treatment Immunotherapy medicine.disease medicine.disease_cause PD-L1 Carcinoma medicine biology.protein Cancer research General Earth and Planetary Sciences Immunohistochemistry T-stage Carcinogenesis business General Environmental Science |
| Zdroj: | Benha Medical Journal. |
| ISSN: | 2357-0016 |
| DOI: | 10.21608/bmfj.2020.130876 |
| Popis: | Background: IMP3, PPARG and PD-L1 have been implicated in tumorigenesis and progression in many cancers, but their significance in urothelial carcinoma remains unclear. Aim: The aim of this study is to assess the possible significance of IMP3, PPARG and PD-L1 in urothelial bladder carcinoma and determine the relation between their expressions and different clinicopathological (tumor size, grade, histological variant, muscle invasion, lymphovascular invasion and pathologic T stage) and molecular variables. Methods: This study aimed to evaluate immunohistochemical expression of IMP3, PPARG and PD-L1 and correlate them with clinicopathological and molecular variables. Results: IMP3 was significantly correlated to muscle invasion (P 0.05).Conclusions: IMP3 may be used as a prognostic marker. PPARG may be used to identify the luminal molecular subtype. PD-L1 may be used as a prognostic marker for tumor aggressiveness, so it may be used in immunotherapy. |
| Databáze: | OpenAIRE |
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