Hopea odorata Extract Can Efficiently Kill Breast Cancer Cells and Cancer Stem-Like Cells in Three-Dimensional Culture More Than in Monolayer Cell Culture
| Autor: | Phong Le Minh, Ngoc Phan Kim, Khuong Duy Pham, Mai Thi-Thanh Nguyen, Phuc Van Pham, Nhan Lu-Chinh Phan, Kiet Dinh Truong |
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| Rok vydání: | 2020 |
| Předmět: |
biology
Cellular differentiation CD44 Cancer biology.organism_classification medicine.disease_cause medicine.disease 03 medical and health sciences 0302 clinical medicine Breast cancer In vivo Cell culture Hopea odorata Cancer research biology.protein medicine 030212 general & internal medicine skin and connective tissue diseases Carcinogenesis |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9783030572532 |
| DOI: | 10.1007/5584_2020_524 |
| Popis: | Introduction The breast cancer cells with CD44+CD24− phenotype are known to play an important role in tumorigenesis, drug resistance, and cancer recurrence. Breast cancer cells with CD44+CD24− phenotype are cultured in three-dimensional (3D) stereotype showing the recapitulation of tumors in vivo such as cell differentiation, heterogeneity, and microenvironment. Using this 3D model in anti-cancer compound research results in a more accurate reflection than conventional monolayer cell culture. This study aimed to identify the antitumor activity of Hopea odorata methanol extract (HO-MeOH-E) on breast cancer cells and cancer stem-like cells in both models of three-dimensional culture (3D) and monolayer cell culture (2D). |
| Databáze: | OpenAIRE |
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