Therapie der okulären Graft-versus-Host-Erkrankung
| Autor: | Christoph Scheid, Uta Gehlsen, S Wittig, Philipp Steven, Claus Cursiefen, Sebastian Siebelmann, Laura Sauerbier, Volkan Tahmaz |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Conjunctiva Visual acuity genetic structures business.industry medicine.medical_treatment Disease progression Hematopoietic stem cell transplantation Disease eye diseases Surgery Ophthalmology surgical procedures operative medicine.anatomical_structure Chronic disease medicine sense organs medicine.symptom business Intensive care medicine Host disease Ocular surface |
| Zdroj: | Klinische Monatsblätter für Augenheilkunde. 232:658-663 |
| ISSN: | 1439-3999 0023-2165 |
| DOI: | 10.1055/s-0035-1545829 |
| Popis: | Therapy for ocular graft-vs-host disease (ocular GvHD) is challenging for ophthalmologists as progress of the disease often occurs rapidly and is unforeseeable. Primary goal is the preservation or restoration of visual acuity, however, studies on ocular GvHD that have investigated therapeutic concepts are limited. In contrast, most therapeutic recommendations from consensus conferences derive from studies on dry eye diseases other than ocular GvHD. This review demonstrates the available therapies in the following categories: local, systemic, surgical and prophylactic. Primary targets are anti-inflammation, anti-fibrosis and lubrification of the ocular surface. In conclusion, studies strictly on ocular GvHD are needed to enable better evidence-based therapeutic decision-making in the future. |
| Databáze: | OpenAIRE |
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