| Autor: |
Valdivia, A., Savoldo, B., Nandi, S., Leon, E., Du, H., Khagi, S., Dotti, G., Gu, Z., Hudson, H., Hingtgen, S., Yazdimamaghani, M., Ligler, F.S., Ogunnaike, E.A. |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| DOI: |
10.17615/bh53-9q67 |
| Popis: |
Regional delivery of chimeric antigen receptor (CAR) T cells in glioblastoma represents a rational therapeutic approach as an alternative to intravenous administration to avoid the blood-brain barrier impediment. Here, we developed a fibrin gel that accommodates CAR-T cell loading and promotes their gradual release. Using a model of subtotal glioblastoma resection, we demonstrated that the fibrin-based gel delivery of CAR-T cells within the surgical cavity enables superior antitumor activity compared to CAR-T cells directly inoculated into the tumor resection cavity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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