Synthesis and antiviral activity of new substituted pyrimidine glycosides

Autor: Ezzat Hagag, Mahmoud M. M. Ramiz, Wael A. El-Sayed, Adel A.-H. Abdel-Rahman
Rok vydání: 2011
Předmět:
Zdroj: Journal of Heterocyclic Chemistry. 48:1028-1038
ISSN: 0022-152X
Popis: A number of N-substituted pyrimidine glycosides were synthesized by coupling reaction of the pyrimidine base with acetobromosugars followed by deprotection. The synthesized compounds were tested for their antiviral activity against Hepatitis B Virus (HBV). Plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with tested compounds which showed moderate to high anti viral activities. J. Heterocyclic Chem., (2011).
Databáze: OpenAIRE