ChemInform Abstract: Facile One-Pot Preparation of 2-Arylpropionic and Arylacetic Acids from Cyanohydrins by Treatment with Aqueous HI

Autor:	Gianluca Bianchini, Alessia Amore, Manolo R. Sablone, Alberto Dolce, Plinio Perrone, Michela Fani, Andrea Aramini, Marcello Allegretti
Rok vydání:	2009
Předmět:	Reaction conditions Aqueous solution Chemistry Reagent Organic chemistry General Medicine Deoxygenation
Zdroj:	ChemInform. 40
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200926087
Popis:	A novel one-pot two-step procedure has been developed to synthesize highly substituted 2-arylpropionic and arylacetic acids, by treatment with aqueous HI, from cyanohydrins. The hydrogenolytic reduction of α-hydroxy-2-arylpropionic acids was the key step of the process and the optimization of the reaction conditions led to identify aqueous HI as an appropriate and selective reagent for the reductive deoxygenation of cyanohydrins. The synthetic route described a general and efficient strategy for the preparation of large libraries of phenylacetic and phenylpropionic acids derivatives.
Databáze:	OpenAIRE
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