| Autor: |
Kenneth Cw Wong, Kenneth K.H. Lai, Hunter Kl Yuen, W.H. Chan, Edwin H.W. Chan, Jimmy Yu, W. C. Lam, Clement C Y Tham, S.K. Ip, Chi Pui Pang, Joyce K.Y. Chin, Y.H. Hui, Emmy Ym Li, Kelvin K.L. Chong, Andy Co Cheng, Theresa S.T. Mak, Ida Y. F. Lo, Jeremy Sw Kwok, N.M Lam, Alvin L. Young, Simon Tc Ko, Kenneth Kw Li, Regine Y.C. Chan, W Cheuk, Wilson W K Yip |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
SSRN Electronic Journal. |
| ISSN: |
1556-5068 |
| Popis: |
Background: Increased risk of developing cancer in patients with Immunoglobulin G4-related disease (IgG4-RD) have been reported. Association of malignancies and IgG4-related ophthalmic disease (IgG4-ROD), however, remains unclear. Methods: A retrospective review of medical records, orbital images and histopathology reports from 2005 to 2019 in a territory-wide, biopsy-proven cohort, fulfilling the “probable” or “definite” comprehensive diagnostic criteria of IgG4-RD. Findings: All 122 patients had biopsies taken from single or multiple ocular adnexal lesions including lacrimal glands (n=108), discrete orbital masses (n=30), infiltrated orbital fat (n=10), conjunctiva(n=2) or extraocular muscles (n=3). Totally 16 (13%) patients developed cancer over 73±48 months’ follow-up. 9 developed ocular adnexal lymphoma (OAL) and 7 had extra-orbital malignancies. The incidence of OAL was significantly higher (standardized incidence ratios (SIRs) =10.0, 95%CI=4.5-17.6) while that of extra-orbital malignancies was similar (SIRs=0.54, 95%CI=0.2-1.0) to the general population. The risk of OAL was highest within the first year of IgG4-ROD diagnosis (SIRs=46.7, 95%CI=18.5-87.6) as 7 of the 9 OAL were diagnosed concomitantly with IgG4-ROD. Patients who developed OAL or extra-orbital malignancies were older at the time of diagnosis of IgG4-ROD compared to the rest of the cohort (64.9±7.1 years and 68.3±8.5 years versus 55.2±15.0 years, both p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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