Microwave-assisted Diels-Alder reaction for rapid synthesis of luminescent nanodiamond with AIE-active dyes and their biomedical applications
| Autor: | Xiangcheng Liu, Jinglong Liu, Zhe Zhao, Xiaoyong Zhang, Qing Wan, Fengjie Deng, Meiying Liu, Zhuoyong Zhang, Yuanqing Wen |
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| Rok vydání: | 2017 |
| Předmět: |
Fluorophore
Materials science Biocompatibility Nanotechnology 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Controlled release Fluorescence 0104 chemical sciences chemistry.chemical_compound chemistry Drug delivery General Materials Science 0210 nano-technology Nanodiamond Biological imaging Diels–Alder reaction |
| Zdroj: | Materials Chemistry and Physics. 197:256-265 |
| ISSN: | 0254-0584 |
| Popis: | Fluorescent nanodiamond (FND) has received increasing research interests for bioimaging and drug delivery owing its outstanding physicochemical properties and low toxicity. However, synthesis of FND in large scale with desirable optical property is still a big challenge. In this work, we reported for the first time that non-fluorescent ND can be facilely converted into FND through surface modified with aggregation-induced emission fluorophore containing luminescent polymers through the microwave-assisted typical Diels-Alder (D-A) reaction. The final FND (named as ND-poly(Phe-PEGMA-IA)) displayed extensive fluorescence, high water dispersibility and desirable biocompatibility. Cell imaging results demonstrated ND-poly(Phe-PEGMA-IA) exhibited great stain performance. Furthermore, anticancer drug (cisplatin, DDP) can be effectively loaded onto ND-poly(Phe-PEGMA-IA) and controlled release it under acidic environment. All of these favorable properties endow ND-poly(Phe-PEGMA-IA) great potential for biological tracing and controlled drug delivery. Taken together, we have developed a microwave-assisted D-A reaction for preparation of multifunctional FND with great potential for biological imaging and controlled drug delivery applications. |
| Databáze: | OpenAIRE |
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