Analysis of proteomic profile changes of Danio rerio embryos during exposure to doxorubicin, incorporated in the phospholipid transport nanosystem

Autor:	O. V. Larina, N. A. Petushkova, O. M. Ipatova, N. F. Samenkova, A. V. Lisitsa, Oxana P. Trifonova, Yu. S. Kisrieva, G P Kuznetsova, I. I. Karuzina
Rok vydání:	2014
Předmět:	animal structures Proteomic Profile biology Clinical Biochemistry Phospholipid Danio Phospholipid transport biology.organism_classification Biochemistry chemistry.chemical_compound Vitellogenin chemistry Proteome medicine biology.protein Molecular Medicine Doxorubicin DNA medicine.drug
Zdroj:	Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 8:108-114
ISSN:	1990-7516 1990-7508
DOI:	10.1134/s1990750814020115
Popis:	The proteome profile of Danio rerio embryos grown in the medium containing doxorubicin, included in the phospholipid transport nanosystem (doxolip) has been investigated using combination of 1D-electrophoresis with subsequent MALDI-TOF-PMF mass spectrometry. Cultivation of growing of D. rerio embryos in the medium with doxolip caused a substantial increase in expression of the cytoskeletal proteins, a decrease in the number of nuclear proteins involved in DNA and RNA synthesis and disappearance of vitellogenin 2 in comparison with control (the cultivation medium containing the phospholipid transport nanosystem). Analysis of the proteomic profiles of doxolip-treated embryos suggests lower toxicity of doxorubicin incorporated in the phospholipid nanosystem.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::844c0e0f2b3514705d037e565dcfa068 https://doi.org/10.1134/s1990750814020115 Zobrazit plný text záznamu Full text from SpringerLink