Magnetic resonance-guided near-infrared tomography of the breast

Autor:	John B. Weaver, Marvin M. Doyley, Ben Brooksby, Christine Kogel, Brian W. Pogue, Shudong Jiang, Steven P. Poplack, Keith D. Paulsen, Hamid Dehghani
Rok vydání:	2004
Předmět:	Photomultiplier Optical fiber Materials science medicine.diagnostic_test business.industry Reconstruction algorithm Iterative reconstruction Laser law.invention Optics law medicine Tomography Optical tomography business Instrumentation Image resolution
Zdroj:	Review of Scientific Instruments. 75:5262-5270
ISSN:	1089-7623 0034-6748
DOI:	10.1063/1.1819634
Popis:	The design and implementation of a multispectral, frequency-domain near infrared tomography system is outlined, which operates in a MRI magnet for utilization of MR-guided image reconstruction of tissue optical properties. Using long silica optical fiber bundles, measurements of light transmission through up to 12 cm of female breast tissue can be acquired simultaneously with MRI scans. The NIR system utilizes six optical wavelengths from 660 to 850 nm using intensity modulated diode lasers nominally working at 100 MHz. Photomultiplier tube detector gain levels are electronically controlled on a time scale of 200 ms, thereby allowing rapid switching of the source to locations around the tissue. There are no moving parts in the detection channels and for each source position, 15 PMTs operating in parallel allow sensitivity down to 0.5 pW/cm2 at the tissue surface. Images of breast tissue optical absorption and reduced scattering coefficients are obtained using a Newton-type reconstruction algorithm to solv...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8444076054726b5bcdd341906e6b0207 https://doi.org/10.1063/1.1819634 Zobrazit plný text záznamu