Development of Synthetic Strategies to Access Optically Pure Feringa’s Motors
| Autor: | Yu-Nan Qin, Quan Li, Guang-Yan Du, Chen Zhang |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Synthesis. 53:4588-4598 |
| ISSN: | 1437-210X 0039-7881 |
| DOI: | 10.1055/a-1577-7850 |
| Popis: | Light-driven unidirectional molecular motors have gained significant attention since the pioneering work by Prof. Ben Feringa in 1999, and they hold great promise as next-generation smart materials. The intrinsic feature of point chirality and the helicity of these molecular motors requires efficient strategies to access their optically pure forms, especially when chirality-sensitive materials are fabricated. In this short review, we summarize synthetic strategies to access optically pure first- and second-generation molecular motors. Three general strategies are discussed: direct asymmetric synthesis, chiral auxiliary methods and chiral separation aided by a resolving agent. We hope that this review will ignite the enthusiasm of synthetic chemists to address very fundamental but unavoidable synthetic questions on chiral-alkene-based molecular motors concerning their large-scale applications.1 Introduction2 Synthesis of First-Generation Molecular Motors2.1 Direct Asymmetric Synthesis of Molecular Motors2.2 Resolving-Agent-Aided Chiral Resolution of Molecular Motors3 Synthesis of Second-Generation Molecular Motors3.1 Direct Asymmetric Synthesis of Molecular Motors3.2 Chiral Auxiliary Strategy3.3 Domino Strategy4 onclusions |
| Databáze: | OpenAIRE |
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