Synthesis of hydroperoxide and perketal derivatives of polyunsaturated fatty acids as potential antimalarial agents
| Autor: | Michael J. Pitt, Alfred Poulos, Christopher J. Easton, L M Kumaratilake, Deborah Ann Rathjen, A. Ferrante, Thomas Robertson |
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| Rok vydání: | 1998 |
| Předmět: |
chemistry.chemical_classification
biology Organic Chemistry Fatty acid Plasmodium falciparum Fatty Acid Hydroperoxides biology.organism_classification Biochemistry chemistry parasitic diseases Drug Discovery medicine Organic chemistry Antimalarial Agent Artemisinin In vitro growth Polyunsaturated fatty acid medicine.drug |
| Zdroj: | Tetrahedron Letters. 39:4401-4404 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/s0040-4039(98)00747-3 |
| Popis: | Hydroperoxide derivatives of beta-oxa-substituted polyunsaturated fatty acids were prepared by 15-lipoxygenase catalysed oxidation and perketal derivatives of fatty acid hydroperoxides were synthesized. The perketals are more stable than their parent fatty acid hydroperoxides, but less active as antimalarial agents in the in vitro growth inhibition of Plasmodium falciparum. (C) 1998 Elsevier Science Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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