Homogeneous Sampling Accounts for the Increased Diagnostic Accuracy Using the ThinPrep™Processor

Autor:	David J. Zahniser, Annekathryn Goodman, Martha L. Hutchinson, Katherine K. Mui, Kurt L. Douglass, Anne A. Hurley, Florence W. Patten, Louise M. Isenstein
Rok vydání:	1994
Předmět:	Pap smears Pathology medicine.medical_specialty business.industry Papanicolaou stain Sampling (statistics) Diagnostic accuracy General Medicine Papanicolaou Test Homogeneous Medicine Specimen Handling Direct smear business Nuclear medicine
Zdroj:	American Journal of Clinical Pathology. 101:215-219
ISSN:	1943-7722 0002-9173
DOI:	10.1093/ajcp/101.2.215
Popis:	Recent clinical trials indicated that the ThinPrep method of sample preparation has greater diagnostic sensitivity than the conventional direct Papanicolaou smear. The authors hypothesized that nonhomogeneous cell sampling during transfer from the sampling device to the microscope slide was a contributing factor to the reduced accuracy of the conventional direct Pap smears in these trials. To test this hypothesis, four direct smear methods were compared with the newly developed, fluid-based, filter-transfer method. Counts of epithelial cells on conventional smears showed that only a fraction of the available epithelial cells on the sampling devices (medians, 6.5% to 62.5%) was actually deposited on the slides. In all 27 cases studied with the ThinPrep method, equivalent diagnostic material was obtained on each of the replicate slides prepared per specimen. This identifies a new source of error, preparation error, in conventional smears.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::841e0961390c2d3246465bbd14ebec28 https://doi.org/10.1093/ajcp/101.2.215 Zobrazit plný text záznamu