Urinary cytology as a tool for differential diagnosis between acute tubular necrosis and proliferative glomerulonephritis in patients with nephrotic syndrome and acute kidney injury
| Autor: | Carlos Alberto dos Santos Silva, Marília Bahiense Oliveira, Washington Lc dos-Santos, Ricardo David Couto, Paula Neves Fernandes, Maria Brandão Tavares, Caroline Vilas Boas de Melo |
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| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty urogenital system business.industry Urinary system Acute kidney injury Glomerulonephritis urologic and male genital diseases medicine.disease female genital diseases and pregnancy complications Cytology medicine In patient Differential diagnosis business Nephrotic syndrome Acute tubular necrosis |
| DOI: | 10.21203/rs.3.rs-42639/v1 |
| Popis: | Objective Acute tubular necrosis (ATN) is a frequent cause of acute kidney injury (AKI). In patients with nephrotic syndrome (NS), AKI demands the differential diagnosis between ATN and rapidly progressive glomerulonephritis. In some cases, conclusive diagnosis is possible only by kidney biopsy. We aimed to study the potential use of urine cytology in the differential diagnosis between ATN and proliferative glomerular lesion in patients with NS.Results Cell size analysis showed a higher proportion of small cells and a lower proportion of large cells in the urine of patients with AKI. Cells phenotypes were easily defined using cytological preparations. Leukocytes were found to be a primary classifier of NS groups, with higher number in patients with AKI and patients with proliferative glomerular lesions. Our data suggests that urinary cytology can be readily performed and support the differential diagnosis between proliferative glomerular lesion and ATN in patients with NS and AKI. |
| Databáze: | OpenAIRE |
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