Lipopolysaccharide-Enhanced Bactericidal Activity is Mediated by Induction of the Autophagosomal Process

Autor:	Michelle L. Snyder, Theresa L. White, Marc Y. Fink, Matthew Weichseldorfer
Rok vydání:	2017
Předmět:	Innate immune system Lipopolysaccharide Pathogen-associated molecular pattern Autophagy Pattern recognition receptor Inflammation Biology Cell biology chemistry.chemical_compound chemistry TLR4 medicine lipids (amino acids peptides and proteins) medicine.symptom Receptor
DOI:	10.1016/b978-0-12-812146-7.00022-6
Popis:	The innate immune system signals through pattern recognition receptors (PRRs) upon recognition of pathogen-associated molecular patterns for the activation of antimicrobial responses. Among the best characterized of the PRRs is Toll-like receptor 4 (TLR4), which is activated upon binding of the bacterial cell wall component lipopolysaccharide (LPS). Recent evidence suggests that among the responses downstream of LPS activation of TLR4 signaling is the induction of autophagy. Autophagosomal processes contribute to the clearance of intracellular bacteria from host cells, and LPS induction of autophagy has been linked to enhanced bactericidal activity. Here we discuss the molecular events that link LPS activation of TLR4 signaling pathways and the induction of autophagy. In addition, we highlight the roles that induction of autophagy has been shown to play on both the activation and regulation of innate immune responses.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::841a5fdd4f8e7fc5c24fa5158a14a628 https://doi.org/10.1016/b978-0-12-812146-7.00022-6 Zobrazit plný text záznamu