Clinicopathological Characteristics of Pseudomyxoma Peritonei Originated from Ovaries
| Autor: | Xin-Bao Li, Feng Shi, Yulin Lin, Yan Li, Chunkai Yu, Fengcai Yan, Mulan Jin |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty endocrine system diseases biology business.industry Ovary medicine.disease Appendix 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis biology.protein Immunohistochemistry Medicine Mucinous carcinoma Pseudomyxoma peritonei Mucinous Tumor Villin business CDX2 |
| Zdroj: | Cancer Management and Research. 12:7569-7578 |
| ISSN: | 1179-1322 |
| DOI: | 10.2147/cmar.s264474 |
| Popis: | Objective This study aims to demonstrate clinicopathological characteristics and immunohistopathological phenotypes of pseudomyxoma peritonei (PMP) originated from ovaries. Methods The primary origin of PMP was explored by reviewing H&E sections retrospectively and performing a series of immunohistochemical staining on CK7, CK20, CDX2, CEA, Villin, SATB2, CA125, ER, PR, and MUC. Results Among 310 PMP patients, a few originated from extra-appendix, whereas eight cases were of ovarian origin (2.6%), including three teratoma-associated ovarian mucinous tumors and five primary ovarian mucinous tumors with spontaneous or iatrogenic rupture, respectively. Most peritoneal metastases were acellular mucin or low-grade mucinous carcinoma peritonei (6/8, 75%), while the rest were high-grade mucinous carcinoma peritonei (2/8, 25%). Tumors were positive for CK20, CDX2, CEA, and Villin. SATB2 was specifically diffuse positive in teratoma-associated ovarian mucinous tumors, and negative in primary ovarian mucinous tumors. Differential expression of MUC was observed in these tumors. Conclusion PMP of ovarian origin is extremely rare. The precise diagnosis requires serial sections of the appendix or suspicious tissue to exclude appendiceal mucinous neoplasms, as well as comprehensive analysis of clinical features, surgical findings, histopathological characteristics, and immunohistochemistry on specific biomarkers. |
| Databáze: | OpenAIRE |
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