Synthesis of a new chiral bisphosphine ligand, MOCBP, and its use in rhodium(I)-catalyzed asymmetric hydrogenation of a cyclic enamide

Autor:	Kazuo Achiwa, Toshiaki Morimoto, Noriya Nakajima
Rok vydání:	1995
Předmět:	Ligand Organic Chemistry Asymmetric hydrogenation chemistry.chemical_element Medicinal chemistry Catalysis Cycloaddition Cyclobutane Rhodium Inorganic Chemistry chemistry.chemical_compound chemistry Organic chemistry Physical and Theoretical Chemistry Efficient catalyst
Zdroj:	Tetrahedron: Asymmetry. 6:75-78
ISSN:	0957-4166
Popis:	A new chiral bisphosphine ligand (6) bearing a cyclobutane framework was readily prepared by using diastereoselective [2+2] cycloaddition. Its rhodium(I) complex was found to be an efficient catalyst for the asymmetric hydrogenation of a cyclic enamide, N-acetyl-1-methylene-1,2,3,4-tetrahydroisoquinoline (9), affording (R)-(−)-N-acetylsalsodine (10) in up to 80.6% ee.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::840ccfaf3826ce6b7f0d96da1088b39e https://doi.org/10.1016/0957-4166(94)00355-f Zobrazit plný text záznamu Full Text from ScienceDirect