XANTHINE OXIDASE INHIBITORY ACTIVITY OF RHUS MYSORENSIS LEAVES

Autor:	Stalin C, Vivekanandan K, Bhavya E
Rok vydání:	2018
Předmět:	Pharmacology chemistry.chemical_classification Traditional medicine Pharmaceutical Science Allopurinol medicine.disease Gout Absorbance chemistry.chemical_compound Enzyme chemistry medicine Uric acid Pharmacology (medical) Hyperuricemia Xanthine oxidase IC50 medicine.drug
Zdroj:	Asian Journal of Pharmaceutical and Clinical Research. 11
ISSN:	2455-3891 0974-2441
DOI:	10.22159/ajpcr.2018.v11s4.31737
Popis:	Objective: The objective of this study was to assess the in vitro xanthine oxidase (XO) inhibiting activity of the methanolic leaf extract of the Rhusmysorensis.Methods: Uric acid is synthesized in the presence of XO which is an essential enzyme. Various concentrations of the leaf extract were taken. XO inhibiting activity was spectrophotometrically assayed. By increasing absorbance at 295 nm, the degree of enzyme spontaneity was determined.Results: Inhibition concentration 50 (IC50) of the methanolic extract of R. mysorensis leaves was 45.24±0.34 μg/ml, compared with IC50 value of the standard allopurinol of 7.8±1.28 μg/ml.Conclusion: Methanol extract of R. mysorensis can be used to treat hyperuricemia and gout after proper preclinical and clinical studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::83ffd6a541554a72347f64d2cd49bb85 https://doi.org/10.22159/ajpcr.2018.v11s4.31737 Zobrazit plný text záznamu