Thoughts on Action of Botulinum Toxin Suggested by Reversibility of Heart Effects

Autor:	Carl Lamanna
Rok vydání:	1993
Předmět:	chemistry.chemical_compound Synaptic cleft Chemistry Vesicle medicine Cholinergic Stimulation Neurotransmitter Botulinum toxin Acetylcholine Exocytosis medicine.drug Cell biology
Zdroj:	Botulinum and Tetanus Neurotoxins ISBN: 9781475795448
DOI:	10.1007/978-1-4757-9542-4_36
Popis:	Botulinum neurotoxin poisoning prevents the release of the neurotransmitter acetylcholine into the synaptic cleft. Stimulation of the cholinergic nerve is required for the acetylcholine-containing vesicles to attach to the inner surface at specific points of the nerve cell synaptic membrane. Thereupon at these points of attachment the acetylcholine leaves the vesicles to escape into the synaptic cleft by passage across the synaptic membrane. This event has been called exocytosis and is probably the action frustrated by the presence of toxin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::83f553b8877373744e5d0b900361d1a5 https://doi.org/10.1007/978-1-4757-9542-4_36 Zobrazit plný text záznamu