| Autor: |
Lars Heggelund, Andreas Barrat-Due, Torleif Lorentsen, Fredrik Müller, Signe Søvik, Martin Andreas Lehre, Ingvild Nordøy, Theresa Olasveengen, Jetmund O. Ringstad, Pål Aukrust, Jan Cato Holter, Anders Tveita, Jan Erik Berdal, Trine Kåsine, Tore Stenstad, Marianne Wigernes Strand |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.21203/rs.3.rs-942078/v1 |
| Popis: |
BacgroundSuper-infections in COVID-19 patients with acute respiratory distress syndrome (ARDS) on mechanical ventilation were initially reported to be rare. Little is known of their incidence after dexamethasone was introduced as standard care. We aimed to determine the incidence and characteristics of superinfections in mechanically ventilated COVID-19 patients during the course of the COVID-19 pandemic, and explore the possible impact of the introduction of dexamethasone as standard therapy. MethodsIn this national, multi-center, observational, retrospective study we included patients ≥ 18 years admitted from March 1 st 2020 to January 31 st 2021 with polymerase chain reaction (PCR)-confirmed SARSCoV-2 infection treated with invasive mechanical ventilation. Data was collected from electronic health records. Patient characteristics, clinical findings, microbiology, length of stay and 90-day survival were examined with backwards stepwise multiple regression. Results155 patients (115 men, mean age 62 years, range 26-84 years) were included. 73 patients (47%) had a total of 101 superinfections where pneumonia dominated (70%). Superinfections were more commonly observed in patients receiving dexamethasone (67% vs 30%, p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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