IC‐P‐156: Association between higher fasting serum glucose levels and the pattern of lower regional gray matter volumes in cognitively normal adults
| Autor: | Stephanie Parks, Pradeep Thiyyagura, Kewei Chen, Jared Bartell, Adam S. Fleisher, Eric M. Reiman, Wendy Lee, Hillary Protas, Christine M. Burns, Alfred W. Kaszniak, Alex X. Li |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Epidemiology business.industry Health Policy Psychiatry and Mental health Cellular and Molecular Neuroscience Endocrinology Developmental Neuroscience Serum glucose Internal medicine Medicine Neurology (clinical) Geriatrics and Gerontology Association (psychology) business |
| Zdroj: | Alzheimer's & Dementia. 9 |
| ISSN: | 1552-5279 1552-5260 |
| Popis: | two subject groups. Results: Ab positive groups had significantly higher HCIs than the Ab negative groups (p1⁄40.0024). HCIs were significantly associated with poorerMMSE and ADAS-Cog scores in the Ab positive group (r1⁄4-0.38, p1⁄40.001 and r1⁄40.36, p1⁄40.002, respectively) but not in the Ab negative group (r1⁄40.007, p1⁄40.936 and r1⁄40.06, p1⁄40.458, respectively). Conclusions: Fibrillar A b burden in cognitively normal older adults is associated with an AD-related index of cerebral hypometabolism, and this index is associated with poorer clinical ratings in those who are Ab positive. |
| Databáze: | OpenAIRE |
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