Study of the polymorphic behaviour of some local anesthetic drugs

Autor:	C. Goldbronn, M. Draghi, D. Giron, P. Piechon, S. Pfeffer
Rok vydání:	1997
Předmět:	Differential scanning calorimetry Tetracaine Polymorphism (materials science) Stereochemistry Chemistry Melting point medicine Physical chemistry Procaine Hydrochloride Thermal analysis Bupivacaine hydrochloride Prilocaine Hydrochloride medicine.drug
Zdroj:	Journal of thermal analysis. 49:913-927
ISSN:	1572-8943 0022-5215
Popis:	The local anesthetic drug tetracaine hydrochloride is described in the Europ. Pharmacopea with a melting point of 148°C or with a range of 134 to 147°C due to the melting points of two other forms. The polymorphic behaviour of tetracaine hydrochloride has been studied by using thermal treatments, storage at 92% r.h., crystallizations and equilibrations with saturated solutions. Samples were characterized by X-ray diffraction, IR, thermal analysis and elemental analysis. Since some findings were difficult to interpret, temperature resolved X-ray diffraction was used additionally for the understanding of the thermal behaviour of tetracaine hydrochloride. In this study the polymorphic behaviour of some other local anesthetic drugs is compared.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::83ddebf7e022c6048177565d96fca6b5 https://doi.org/10.1007/bf01996777 Zobrazit plný text záznamu Full text from SpringerLink