Efficacy and safety of esomeprazole with flupentixol/melitracen in treating gastroesophageal reflux disease patients with emotional disorders
| Autor: | Dian-Chun Fang, Yan Cao, Yan-Yan Yu, Zhi-Lin Wu, Chun-Hui Lan, Hui Chang, Li-lin Fan |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Hepatology business.industry Gastroenterology Melitracen medicine.disease Esomeprazole Flupentixol law.invention Flupentixol/melitracen Randomized controlled trial law Anesthesia Internal medicine GERD Medicine Anxiety medicine.symptom business Adverse effect medicine.drug |
| Zdroj: | Journal of Gastroenterology and Hepatology. 29:1200-1206 |
| ISSN: | 0815-9319 |
| DOI: | 10.1111/jgh.12552 |
| Popis: | Background and Aim This study was designed to demonstrate the safety and efficacy of esomeprazole combined with flupentixol/melitracen for the treatment of gastroesophageal reflux disease (GERD) patients with emotional disorders. Methods Two hundred eighty-nine GERD patients with emotional disorders were divided randomly into two groups: group 1 received esomeprazole only (monotherapy) and group 2 received esomeprazole and flupentixol/melitracen (combination therapy). The patients' GERD questionnaire (GerdQ) and hospital anxiety and depression (HAD) scores were obtained before and after treatment. Changes in the scores, rates of symptom remission, and adverse effects were compared between the two groups. Results After 2 weeks of treatment, the average decrease in GerdQ score in the combination group (4.04 ± 2.34) was significantly greater than that in the monotherapy group (3.34 ± 2.74; P |
| Databáze: | OpenAIRE |
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