Toxicological overview of a novel strobilurin fungicide, orysastrobin

Autor:	Heinz Kieczka, Masaki Osawa, Uwe Kaspers, W. Kaufmann, Steffen Schneider, Georgia Coelho Palermo Cunha, Robert Landsiedel, Bennard van Ravenzwaay, Masako Akiyama
Rok vydání:	2007
Předmět:	endocrine system medicine.medical_specialty Health Toxicology and Mutagenesis Thyroid Biology Acute toxicity Epithelium medicine.anatomical_structure Endocrinology Mechanism of action In vivo Insect Science Internal medicine Follicular phase medicine Duodenum medicine.symptom Carcinogen
Zdroj:	Journal of Pesticide Science. 32:270-277
ISSN:	1349-0923 1348-589X
DOI:	10.1584/jpestics.g06-52
Popis:	Orysastrobin is effective against major fungal diseases of rice plants. Acute toxicity is moderate and no skin or eye irritation or skin sensitisation occurred. Secondary, adaptive and reversible, changes in the duodenal mucosa (increased proliferation of the epithelium to increase iron absorption) and thyroid (increased proliferation of follicular cells to increase thyroid hormone synthesis) resulted in increased tumor incidence in the duodenum of rats and mice, and in the thyroid of male rats. In view of a reversible mechanism of action with a clear threshold dose and the absence of mutagenic potential in vivo, and the well-established excessive sensitivity of rats to TSH elevation, orysastrobin is not considered to present a carcinogenic risk to humans. The compound was not selectively toxic to reproduction. The ADI should be derived from a chronic rat study with a NOAEL of 100 ppm.
Databáze:	OpenAIRE
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