Efficient nickel-catalyzed hydrocyanation of alkenes using acetone cyanohydrin as a safer cyano source
| Autor: | Tsuyoshi Nagafuchi, Sato Kazuhiko, Koji Nemoto, Kenichi Tominaga |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Alkene Organic Chemistry chemistry.chemical_element Zinc 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Nickel chemistry Drug Discovery Hydrocyanation Organic chemistry Cyanohydrin Phosphine Acetone cyanohydrin |
| Zdroj: | Tetrahedron Letters. 57:3199-3203 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2016.06.036 |
| Popis: | An active nickel catalyst prepared in situ from a Ni(II) compound, phosphine ligand, and zinc powder was found to be an efficient catalyst system for the hydrocyanation of various alkenes using acetone cyanohydrin as a safer cyano source. The combination of NiCl2·6H2O and 1,3-bis(diphenylphosphino)propane was the most efficient catalyst precursor in DMF. Under the optimized conditions, various styrenes, heterocyclic alkenes, and aliphatic alkenes were converted to their corresponding nitriles in excellent yields. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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