ChemInform Abstract: Oxygen Alkylation of Schiff Base Derivatives of Amino Acids

Autor:	David B. Rusterholz, Gwendolyn K. Cook, Martin J. O'Donnell
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Schiff base Imine General Medicine Alkylation Amino acid law.invention chemistry.chemical_compound chemistry law Benzophenone Organic chemistry Walden inversion Saponification Alkyl
Zdroj:	ChemInform. 23
ISSN:	0931-7597
DOI:	10.1002/chin.199219289
Popis:	Higher imine esters 1a-h and 7a-b of amino acids and dipeptides are prepared in 68-91 % yield by saponification of the benzophenone Schiff base methyl esters 3a-d and 6 using phase-transfer techniques followed by O-alkylation with an alkyl halide. The procedure occurs with retention of configuration at the α-carbon except with phenylglycine derivatives
Databáze:	OpenAIRE
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