Recherches dans la série de la quinoléine: Préparation et oxydation du chlorhydrate de (1-quinoléinio)acétate
| Autor: | M. Mottier |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
chemistry.chemical_classification
Base (chemistry) Stereochemistry Decarboxylation Organic Chemistry Quinoline Chloroacetic acid Biochemistry Medicinal chemistry Chloride Catalysis Inorganic Chemistry chemistry.chemical_compound chemistry Benzyl benzoate Drug Discovery Acetone medicine Physical and Theoretical Chemistry medicine.drug |
| Zdroj: | Helvetica Chimica Acta. 58:337-343 |
| ISSN: | 0018-019X |
| DOI: | 10.1002/hlca.19750580202 |
| Popis: | Reaction of quinoline with chloroacetic acid yields N-carboxymethyl-quinolinium chloride (1) (75%), which is oxidised by K3Fe(CN)6 in the presence of a base to N-carboxymethyl-2-quinolone (2) (70%). If 2 is heated in pure form at 300°, 1,3-Bis(2-quinolon-1-yl)acetone (4) (43%) is obtained; the expected N-methyl-2-quinolone (5) is formed by decarboxylation of 2 in benzyl benzoate at 275° (34%). |
| Databáze: | OpenAIRE |
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